Wednesday, 11th October 8th Venoms to Drugs 2023

• The pathogenesis role of T lymphocytes in rheumatoid arthritis (RA) has been extensively studied. - Christine Beeton
• The Sobering Sting: A Novel Cone Snail Venom-Derived Antagonist of Cannabinoid Receptors - Steve Peigneur
• Vm24 and its transcriptome analysis-based synthetic analogue, sVmKTx, inhibit Kv1.3 K⁺ channels of T lymphocytes with high selectivity and affinity  - Gyorgy Panyi
• Infensa Bioscience and Institute for Molecular Bioscience, the University of Queensland. - Mark Smythe

All speakers with a duration of 30 minutes will have 25 minutes to speak and 5 minutes for questions.

• Deciphering peptidergic signaling and doppelganger toxins: insights into their molecular evolution and therapeutic potential - Thomas Koch
• Unveiling the nemertides: Uncovering novel peptide toxin families in ribbon worms, targeting VGSCs. - Håkan S Andersson
• Variable peptide processing of a Conus cf. neocostatus α-conotoxin generates bioactive toxiforms that are potent against different nicotinic acetylcholine receptor subtypes - Cydee Marie V. Ramones
• Mass Spectrometry Imaging analysis of cryo and ultrathin cryo sections reveals macro and micro scale distribution of Latrunculin-A in Chromodoris kuiteri. - Brett Hamilton
• Genome mining biodiversity collections for novel compounds - Liz Milla
• Unraveling lepidopterism caused by Thaumetopoea processionea by combined transcriptomics, proteomics and ex vivo validation. - Andrea Seldeslachts
• Mending achy breaky hearts: Cyclic peptides inhibitors of ASIC1a as therapeutics for ischemic heart disease  - Daniela Rojas-Azofeifa
• Pharmacological characterization of the spider venom-derived peptide Na_V1.8 modulator Tsp2a - Ashvriya Thapa
• Somatostatin receptor 4 activating conotoxins inspiring a new class of pain therapeutics - Walden E. Bjørn-Yoshimoto
• Structure, function, and evolution of toxins produces by nettle caterpillar (Limacodidae) - Mohaddeseh H Goudarzi

• Evolution of toxin-encoding genes: not as simple as duplication followed by neofunctionalisation - Ivan Koludarov
• Proteotranscriptomics of the popular host sea anemone Entacmaea quadricolor reveals venom composition alters during symbiosis with Amphiprion percula and the evolution of unique functional protein scaffolds - Catherine A Abbott
• From microbiomes to microbes, molecules and medicines – maybe! - Rob Capon

All speakers with a duration of 30 minutes will have 25 minutes to speak and 5 minutes for questions.

• Snake Neurotoxins and Recombinant Antivenoms: Evaluation and Screening using High Throughput Automated Patch Clamp - Rasmus Bjørn Jacobsen
• Discovery of novel RaPID-derived macrocyclic peptide for blockade of the CD24-Siglec-10 interaction as a potential immune checkpoint inhibitor - Wei-En Huang
• Developing a soybean leaf disc assay for determining oral insecticidal activity in Helicoverpa armigera pest caterpillars - Yachen Wang
• Peptide Neurotoxins from Stinging Nettle ‘Venom’ - Thomas Durek
• The venom composition of Tarantula hawk wasps - Vanessa Schendel
• Development and validation of nerve-targeted bacteriochlorin sensors - Chun Yuen Chow
• Pain-causing stinging nettle toxins target tmem233 to modulate na_v1.7 function - Jennifer R Deuis
• Tmem233 is a novel na_v-interacting protein targeted by the stinging nettle toxin extxa - Tabea Klasfauseweh
• Utilising blood-feeding arthropods to identify novel coagulotoxins and ion channel modulators - Raine S Mercedes
• Development of venom-derived peptides as gut-specific therapeutics to target mucosal biofilms in patients with gastrointestinal disorders - Bernhard Jandl
• Structure–activity relationships of tst2: a novel trpv1 inhibitory peptide from the Australian sea anemone telmatactis stephensoni - Renad Albar
• Hydroxylation Of Prolines In Mu Conotoxins Increase Structural Stability And Potency At Sodium Channels. - Victoria Adegoke
• An Integrated In-Silico Pipeline To Elucidate Complex Peptide Binding Motifs - Isaac Tucker

Deciphering peptidergic signaling and doppelganger toxins: insights into their molecular evolution and therapeutic potential - Thomas Koch

Unveiling the nemertides: Uncovering novel peptide toxin families in ribbon worms, targeting VGSCs. - Håkan S Andersson

Variable peptide processing of a Conus cf. sulcatus α-conotoxin generates bioactive toxiforms that are potent against different nicotinic acetylcholine receptor subtypes - Cydee Marie V. Ramones

Mass Spectrometry Imaging analysis of cryo and ultrathin cryo sections reveals macro and micro scale distribution of Latrunculin-A in Chromodoris kuiteri. - Brett Hamilton

Genome mining biodiversity collections for novel compounds - Liz Milla

Unraveling lepidopterism caused by Thaumetopoea processionea by combined transcriptomics, proteomics and ex vivo validation. - Andrea Seldeslachts

Mending achy breaky hearts: Cyclic peptides inhibitors of ASIC1a as therapeutics for ischemic heart disease  - Daniela Rojas-Azofeifa

Pharmacological characterization of the spider venom-derived peptide Na_V1.8 modulator Tsp2a - Ashvriya Thapa

Somatostatin receptor 4 activating conotoxins inspiring a new class of pain therapeutics - Walden E. Bjørn-Yoshimoto

Structure, function, and evolution of toxins produces by nettle caterpillar (Limacodidae) - Mohaddeseh H Goudarzi