Ecology is the science of context – an organism’s relationships with other organisms make it what it is, both synchronically (in any given moment) and diachronically (over developmental and evolutionary time). Venom is a secretory mixture of toxic molecules which mediate interactions between venomous organisms and target organisms: venom is an intrinsically ecological trait and toxins are ecomolecules. Thus, the composition of venom is not only shaped by the encounters between predators and prey in which it is deployed, but the structure-function relationships of individual toxins are shaped by encounters with their molecular targets. In fact, all biomolecules are ecomolecules in that their functions arise only as a consequence of interaction with other molecules in specific contexts, i.e., within molecular ecologies. Toxins and other exochemicals are special, however, in that they transcend the molecular ecologies internal to the organisms that produce them and enter the molecular ecologies of target organisms. In this talk I will discuss the central role of context in shaping function and articulate the usefulness of an ecological stance for the study of toxins and venom, using diverse examples from molecular to organismal evolution. I will utilise a dynamical systems perspective to describe toxins and other exochemical molecules as a method of chemically hacking another organism’s physiology in order to disrupt or recalibrate its target states. This framework unites venom toxins, the exochemicals utilised in symbiotic relationships including parasitism, and the human use of toxins as tools (i.e., drugs), under the shared rubric of targeted manipulation of regulatory pathways contributing to the homeorhetic maintenance of biochemical states in order to shift them from one regime, or basin of attraction, to another.